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Kaya and colleagues have stated that after sciatic nerve injury the density and thickness of myelinated fibres were higher in animals treated with melatonin and kept at a normal illumination cycle than in the animals treated with melatonin and kept at an inverted cycle, yet no quantification and statistical analysis have been provided by the authors (Kaya et al., 2013)

While the use of rodents and small mammals is common for the development of novel therapeutic agents, it is recommended that caution should still be utilized when extrapolating available research to the clinical setting

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